Table 1.
Patient | Age | Gende r |
Ethnicity | KPS* | IDH | MGMT promoter |
Initial surgery |
1st line treatment | 2nd line treatment | Subsequent lines of treatment | OS** |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 36 | female | white | 100 | wt | unmethylated | STR | RT/TMZ+TMZx4 cycles | Resection followed by indoximod+TMZx2 cycles | Bevacizumab+VB111; re-RT+TMZ+bevacizumab | 5.5 |
2 | 63 | male | white | 100 | wt | methylated | STR | RT/TMZ+TMZx3 cycles | Indoximod+TMZx3 cycles | Bevacizumab; durvalumab+tremiliimumab; lomustine+bevacizumab | 24+ |
3 | 46 | male | Hispanic | 100 | wt | unmethylated | GTR | RT/TMZ+TMZ/TTFx3 cycles | Indoximod+TMZx1 cycle | NA | 2 |
KPS, Karnofsky Performance Score; IDH, isocitrate dehydrogenase; wt, wild type; MGMT, methyl-guanine methyl transferase; OS, overall survival; TMZ, temozolomide; TTF, tumor treating fields; RT, radiation therapy; NA, not applicable.
at time of initiation of indoximod+temozlomide
measured in months from after initiation of indoximod with temozolomide.