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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: J Neurooncol. 2018 Nov 10;141(1):111–120. doi: 10.1007/s11060-018-03013-x

Table 1.

Patient Age Gende
r
Ethnicity KPS* IDH MGMT
promoter
Initial
surgery
1st line treatment 2nd line treatment Subsequent lines of treatment OS**
1 36 female white 100 wt unmethylated STR RT/TMZ+TMZx4 cycles Resection followed by indoximod+TMZx2 cycles Bevacizumab+VB111; re-RT+TMZ+bevacizumab 5.5
2 63 male white 100 wt methylated STR RT/TMZ+TMZx3 cycles Indoximod+TMZx3 cycles Bevacizumab; durvalumab+tremiliimumab; lomustine+bevacizumab 24+
3 46 male Hispanic 100 wt unmethylated GTR RT/TMZ+TMZ/TTFx3 cycles Indoximod+TMZx1 cycle NA 2

KPS, Karnofsky Performance Score; IDH, isocitrate dehydrogenase; wt, wild type; MGMT, methyl-guanine methyl transferase; OS, overall survival; TMZ, temozolomide; TTF, tumor treating fields; RT, radiation therapy; NA, not applicable.

*

at time of initiation of indoximod+temozlomide

**

measured in months from after initiation of indoximod with temozolomide.