. Author manuscript; available in PMC: 2020 May 1.

Published in final edited form as: Neurochem Int. 2019 Feb 26;125:151–162. doi: 10.1016/j.neuint.2019.02.015

Table 2.

Amino acid content in visual cortex as a function of increasing vigabatrin administered subcutaneously

Description	Metabolite	Vehicle	35 mg/kg/d	70 mg/kg/d	140 mg/kg/d
Drug	Vigabatrin	-	1.7 (0.4)	9.7 (1.0)	10.9 (3.3)
Drug-Related	Carnosine	55 (3)	65 (3)	76 (5)^a	78 (4)^a
Neutral Amino Acids	Glycine	1331 (42)	1443 (68)^b	1825 (69)^a	1337 (65)^c
	Alanine	1075 (93)	911 (42)	1876 (54)^d	874 (34)
	Serine	1111 (31)	1059 (42)	1026 (25)	954 (44)^a
	Threonine	475 (34)	478 (39)	619 (45)^c	373 (43)
Basic Amino Acids	Arginine	152 (7)	126 (6)^e	157 (8)	169 (14)

Legend: nmol/g tissue (mean ± (SEM))

p<0.05 compared to vehicle

p<0.05 between 35 and 140 dosing

p<0.05 between 70 and 140 dosing

p<0.05 compared to all other dosing (including vehicle)

p<0.05 between 35 and 140 dosing. As an irreversible inhibitor of GABA-transaminase (GABA-T), vigabatrin is predicted to elevate both GABA and β-alanine (the latter a substrate for GABA-T). Carnosine is the L-histidine dipeptide of β-alanine. Animal numbers (n) were: n=21 for vehicle; n=8 for 35 mg/kg/d; n=6 for 70 mg/kg/d; and n=8 for 140 mg/kg/d.