Figure 4.

ceRNA regulatory network associated with the MAPK signaling pathway. Two miRNAs (hsa-miR-124 and hsa-miR-7) and three lncRNAs (LINC00028, LINC00323, and SNHG1) could regulate three mRNAs (RAP1B, ATF2 and PPM1B) that participate in the MAPK signaling pathway. lncRNA, long non-coding RNA; miRNA/miR, microRNA; ceRNA, competing endogenous RNA; LINC, long intergenic non-protein coding RNA; SNHG1, small nucleolar RNA host gene 1; RAP1B, Ras-related protein Rap-1b; ATF2, activating transcription factor 2; PPM1B, protein phosphatase Mg²⁺/Mn²⁺ dependent 1B; MAPK, mitogen-activated protein kinase.