Table I.
Gene Ontology functional enrichment analysis in terms of biology process, cellular component and molecular function for the prognosis-associated mRNAs.
| Category | Term | Count | P-Value | Genes |
|---|---|---|---|---|
| BP | GO:0043009~chordate embryonic development | 16 | 0.0033 | MAFG, NBN, SYVN1, ADA, HOXA2, HOXA3, HOXC9, MEOX2, HOXA5, HOXB8, NCOA6, APBA3, DAD1, MAPK8IP3, ROR2, MED1 |
| GO:0048568~embryonic organ development | 10 | 0.0086 | HOXA2, HOXC9, HOXA3, HOXB8, HOXA5, MYO7A, ROR2, VAX2, ADA, MED1 | |
| GO:0003002~regionalization | 10 | 0.0195 | HOXA2, HOXC9, HOXA3, BTG2, MEOX2, HOXB8, HOXA5, ROR2, VAX2, LRP5 | |
| GO:0051276~chromosome organization | 18 | 0.0208 | MEAF6, NBN, HIST1H1D, HIST1H2BF, HP1BP3, HIST1H1A, EZH2, CENPE, TSPYL1, CHMP1A, EYA2, HDAC2, NCAPG, PRDM5, CHD1,TLK1, RNF40, KDM5D | |
| GO:0001501~skeletal system development | 13 | 0.0296 | ESRRA, AEBP1, BMP1, TUFT1, ATP6V1B1, HOXA2, HOXA3, HOXC9, HOXB8, HOXA5, ETS2, COMP, ROR2 | |
| GO:0006351~transcription, DNA-dependent | 12 | 0.0367 | TAF11, TAF1B, MED7, CCNK, TAF1A, ETS1, ANG, NCOA6, NFIX, POLR2D, MED1, TAF1L | |
| GO:0032774~RNA biosynthetic process | 12 | 0.0399 | TAF11, TAF1B, MED7, CCNK, TAF1A, ETS1, ANG, NCOA6, NFIX, POLR2D, MED1, TAF1L | |
| GO:0045597~positive regulation of cell differentiation | 10 | 0.0448 | IKZF1, ETS1, VHL, MAPT, KITLG, SEMA4D, SOCS5, NTN1, BOC, ADA | |
| GO:0006325~chromatin organization | 14 | 0.0458 | MEAF6, HIST1H1D, HP1BP3, HIST1H2BF, HIST1H1A, EZH2, TSPYL1, EYA2, HDAC2, PRDM5, CHD1, TLK1, RNF40, KDM5D | |
| GO:0048598~embryonic morphogenesis | 12 | 0.0495 | HOXA2, EYA2, HOXC9, HOXA3, HOXB8, HOXA5, MYO7A, CRABP2, ROR2, VAX2, MED1, LRP5 | |
| CC | GO:0044463~cell projection part | 15 | 0.0002 | PLD2, BBS5, PARD3, TTLL6, KLC2, GAS8, ADA, SPAG16, PCSK1, CC2D2A, CYBRD1, MAPK8IP3, PEBP1, SLC5A6, CNTNAP1 |
| GO:0042995~cell projection | 26 | 0.0017 | BBS5, PARD3, MYO7A, CLSTN1, TTLL6, KLC2, ADA, SPAG16, PCSK1, ANG, MAPT, SLC4A7, CNTNAP1, PLD2, DBNL, ARHGEF7, NPY1R, GAS8, THY1, GRM2, CC2D2A, CYBRD1, PEBP1, MAPK8IP3, SLC5A6, GAP43 | |
| GO:0005694~chromosome | 19 | 0.0030 | TCP1, NBN, HIST1H1D, PRPF4B, IKZF1, HIST1H2BF, PPP2R5A, HP1BP3, HIST1H1A, AKAP8L, CENPE, TRIM66, CHMP1A, HDAC2, RIF1, NCAPG, PPP2CB, CHD1, RNF40 | |
| GO:0044427~chromosomal part | 15 | 0.0158 | TCP1, NBN, HIST1H1D, IKZF1, HIST1H2BF, HP1BP3, PPP2R5A, HIST1H1A, CENPE, TRIM66,HDAC2, RIF1, NCAPG, PPP2CB, CHD1 | |
| GO:0005578~proteinaceous extracellular matrix | 13 | 0.0195 | ASPN, COL4A2, HMCN1, ADAMTSL2, LAMC3, ANG, FBLN2, COMP, TIMP4, MMP3, NTN1, MFAP5, SPON1 | |
| GO:0043005~neuron projection | 13 | 0.0306 | ARHGEF7, NPY1R, KLC2, ADA, THY1, PCSK1, GRM2, ANG, MAPT, MAPK8IP3, PEBP1, CNTNAP1, GAP43 | |
| GO:0031012~extracellular matrix | 13 | 0.0322 | ASPN, COL4A2, HMCN1, ADAMTSL2, LAMC3, ANG, FBLN2, COMP, TIMP4, MMP3, NTN1, MFAP5, SPON1 | |
| GO:0005730~nucleolus | 21 | 0.0440 | UTP23, MEAF6, PNMA3, NBN, SYVN1, TAF1A, TSR1, HNRNPA1, PNN, TSPYL1, NOP14, STAT6, DIS3, KRT17, ANG, RPL9, NCOA6, PQBP1, LIAS, HNRNPH1, ARL4A | |
| MF | GO:0043565~sequence-specific DNA binding | 22 | 0.0116 | MAFG, TSHZ3, ERF, ESRRA, IKZF1, TFE3, VAX2, NFIX, ATF2, STAT6, ATF5, HOXA2, HDAC2, HOXA3, HOXC9, MEOX2, HOXA5, ETS1, HOXB8, ETS2, PRDM5, CREB3L4 |
| GO:0030528~transcription regulator activity | 41 | 0.0440 | TAF1B, TSHZ3, AEBP1, TAF1A, TFE3, E2F8, EZH2, CNOT3, NFIX, MXI1, ATF2, ZNF75D, KCNIP3, STAT6, TRIM66, HOXA2, HOXC9, HOXA3, HOXA5, PQBP1, CREB3L4, TAF1L, MAFG, ERF, ESRRA, IKZF1, VAX2, AFF1, MSRB2, TAF11, MED7, ATF5, HDAC2, MEOX2, ETS1, HOXB8, ETS2, PRDM5, NCOA6, ID4, MED1 |
GO, Gene Ontology; BP, biology process; CC, cellular component; MF, molecular function.