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. 2019 Feb 26;43(4):1575–1584. doi: 10.3892/ijmm.2019.4109

Figure 6.

Figure 6

ACE2/ACE axis imbalance and apoptotic signaling proteins, and p-ERK1/2 in the left myocardium of APE-CA and ROSC pigs as determined by immunohistochemistry. (A) Correlation between the ACE2/ACE axis and apoptosis-associated proteins. (B) Representative images. Black arrows indicate staining for p-ERK1/2 (scale bar, 100 µm). (C) Quantitative analysis of immunohistochemical staining. N=5 pigs per group. **P<0.01; ***P<0.001 vs. the control group; #P<0.05; ##P<0.01 vs. the APE-CA group; &P<0.05 vs. the ROSC-SA group. APE-CA, acute pulmonary embolism with cardiac arrest; ROSC, return of the spontaneous circulation; SA, saline; Cap, captopril; p-ERK, phosphorylated extracellular signal-regulated kinase.