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. 2019 Jan 31;43(4):1643–1656. doi: 10.3892/ijmm.2019.4086

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Copyright: © Sheu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Network of top 5 upstream regulators and dysregulated genes in idiopathic pulmonary fibrosis fibroblasts. The top 5 upstream regulators, including FBN1, BRD4, GATA6, TSIX and RFX5, were generated using Ingenuity^® Pathway Analysis based on the significance of overlap between the dysregulated genes and the genes that were regulated by the upstream regulators. The dysregulated genes targeted by these top upstream regulators were COL1A2, COL4A1 and COL4A2, all belonging to the fibrillar collagen family. Numbers in parentheses are the number of reports supporting interactions. E, expression; FC, expression fold-change; PD, protein-DNA binding; CLO1A2, collagen alpha-2(I) chain; COL4A1, collagen alpha-1(IV) chain; COL4A2, collagen alpha-2(IV) chain; FBN1, fibrillin-1; BRD4, bromodomain-containing protein 4; GATA6, transcription factor GATA-6; RFX5, DNA-binding protein RFX5.