Table IV.
Gene Expression Omnibus verification of 42 dysregulated genes in IPF fibroblasts.
| A, Upregulated genes
| |||||
|---|---|---|---|---|---|
| Genes | Fold-change |
GSE44723
|
GSE24206
|
||
| Up-/Downregulation | P-value | Up-/Downregulation | P-value | ||
| HSPA12B | 18.15 | N/A | - | Up | 0.835 |
| NTM | 13.94 | Up | 0.257 | Up | 0.010 |
| PAX8 | 6.35 | Up | 0.341 | Up | 0.032 |
| MKI67 | 5.15 | Down | 0.582 | Up | 0.017 |
| POSTN | 5.14 | Down | 0.688 | Up | 0.008 |
| MYO1C | 5.04 | Down | 0.810 | Up | 0.259 |
| LINC01529 | 3.24 | N/A | - | N/A | - |
| COL1A2 | 2.97 | Down | 0.397 | Up | <0.001 |
| CCNL1 | 2.88 | Up | 0.737 | Down | <0.001 |
| ATP2B4 | 2.78 | Up | 0.147 | Up | 0.159 |
| ANP32B | 2.74 | Up | 0.443 | Down | 0.159 |
| PKMYT1 | 2.69 | Down | 0.929 | Up | 0.832 |
| GAB2 | 2.63 | Down | 0.873 | Down | <0.001 |
| GPM6B | 2.57 | Up | 0.890 | Down | 0.013 |
| TDG | 2.45 | N/A | - | Down | 0.113 |
| HSPA8 | 2.40 | N/A | - | Up | 0.081 |
| CD248 | 2.32 | Down | 0.255 | Up | 0.115 |
| LINC00847 | 2.19 | Down | 0.053 | Up | 0.091 |
| ANKRD18EP | 2.17 | N/A | - | N/A | - |
| CNN3 | 2.11 | N/A | - | Down | 0.095 |
| MESD | 2.09 | Up | 0.958 | Up | 0.002 |
| IQGAP1 | 2.02 | Up | 0.437 | Down | 0.717 |
| LINC01291 | 2.01 | N/A | - | N/A | - |
|
| |||||
| B, Downregulated genes | |||||
|
| |||||
| TYW1 | -6.06 | Up | 0.201 | Down | 0.716 |
| COL4A1 | -5.81 | Down | 0.224 | Up | 0.354 |
| AKAP12 | -5.45 | Up | 0.410 | Down | 0.004 |
| ITPRID2 | -4.82 | Down | 0.019 | Down | 0.031 |
| PRKAR1B | -4.33 | Down | 0.194 | Up | 0.767 |
| INKA2 | -4.14 | Down | 0.213 | Down | 0.001 |
| AKAP2 | -3.88 | N/A | - | Down | 0.007 |
| GPR17 | -3.51 | N/A | - | Down | 0.460 |
| FAM151A | -3.15 | N/A | - | Down | 0.081 |
| UXT-AS1 | -3.10 | N/A | - | N/A | - |
| IL17RC | -2.88 | Down | 0.841 | Down | 0.630 |
| SPDYE6 | -2.88 | N/A | - | Down | 0.220 |
| MED31 | -2.73 | Up | 0.478 | Up | 0.831 |
| FEM1B | -2.38 | Up | 0.873 | Down | 0.024 |
| NCL | -2.35 | N/A | - | Down | 0.166 |
| PTX3 | -2.19 | Up | 0.918 | Down | <.001 |
| OR7E12P | -2.12 | N/A | - | Down | 0.937 |
| SPON1 | -2.06 | Up | 0.986 | Down | 0.036 |
| COL4A2 | -2.01 | Down | 0.214 | Up | 0.584 |
Fold-change indicates the results of RNA-seq analysis from the next-generation sequencing data. GEO, Gene Expression Omnibus; IPF, idiopathic pulmonary fibrosis; N/A, not available.