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. 2019 Jan 30;43(4):1611–1622. doi: 10.3892/ijmm.2019.4084

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Immunohistochemical distribution of the expression of OPN and MCP-1 in rat kidneys harvested following an 8-week treatment period. The left column comprises representative images showing the expression of OPN and MCP-1 in control rats, the middle column comprises representative images showing the expression of OPN and MCP-1 in EG-treated rats and the right column comprises representative images showing the expression of OPN and MCP-1 in EG + metformin-co-treated rats. OPN, osteopontin; MCP-1, monocyte chemoattractant protein 1; EG, ethylene glycol.