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. Author manuscript; available in PMC: 2020 Apr 28.
Published in final edited form as: Cancer Lett. 2019 Feb 11;448:155–167. doi: 10.1016/j.canlet.2019.02.005

Table 1.

Summary of Ingenuity Pathway Analysis.

Pathway Analysis P-value
Top Canonical Pathways
EIF2 Signaling 5.30E-09
Regulation of eiF4 and p70S6K Signaling 1.32E-06
Cell Cycle Control of Chromosomal Replication 1.55E-06
Top Upstream Regulators
MYC 1.13E-10
E2F1 1.71E-09
sirolimus 1.76E-06
Top Molecular and Cellular Functions
RNA Post-Transcriptional Modification 2.10E-04 – 3.84E-11
Cell Death and Survival 7.01E-03 – 4.77E-10
Cell Cycle 7.01E-03 – 6.80E-9
Protein Synthesis 8.29E-04 – 1.72E-07
Top Diseases
Cancer 7.01E-03 – 2.31E-08
Organismal Injury and Abnormalities 7.01E-03 – 2.31E-08
Tumor Morphology 6.35E-03 – 2.31E-08
Top Networks
Cell Morphology, Cellular Function and Maintenance
Cell Cycle, Cell Death and Survival, Cellular Assembly and Organization
Protein Synthesis, RNA Post-Transcriptional Modification

The includes shared analysis between Microarray and Proteomics ± JUND of down-regulated (p<0.05) molecules.