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. 2019 Mar 6;13:43. doi: 10.3389/fnbeh.2019.00043

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Copyright © 2019 Liu, Zhu, Hao, Shi, Wang, Xue and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NE induced PTSD-like memory impairments via down-regulation the expression of Ser845 and Ser831 phosphorylation of GluR1. (A) Representative immunoblots showing the effect of the bilateral intra-BLA infusion of NE (0.3 μg/0.2 μl) or propranolol (5 μg/0.2 μl) immediately after fear conditioning induced change in phospho-GluR1 and total GluR1 levels. (B) Representative immunoblots showing the effect of the bilateral intra-BLA infusion of NE with the different doses of NE (0.1, 0.3, or 1.0 μg/0.2 μl) immediately after training induced change in phospho-GluR1 and total GluR1 levels. All results represent mean ± SEM. *P < 0.05, **P < 0.01, vs. vehicle group.