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. 2019 Mar 6;10:315. doi: 10.3389/fimmu.2019.00315

Figure 3.

Figure 3

Box plots of serum/plasma concentration of active ATG in ATG-GENZ (Genzyme) and ATG-FRES (Fresenius) treated patients depending on the given total ATG dose. At week 0 (day of graft infusion) the ATG-GENZ patients receiving a total ATG dose of 10 mg/kg had a significantly higher serum/plasma level of active ATG than the 6–8 mg/kg receiving patients. Active ATG in ATG-FRES treated patients was at week 0 comparable between 45 and 60 mg/kg total ATG dose receiving patients and higher than in ATG-GENZ treated patients. At week +3 post-HSCT the serum/plasma level of active ATG in ATG-GENZ treated patients was still strongly dependent on the given dose (1.29 and 0.11 AU/mL), but the active ATG concentration in ATG-FRES treated patients was comparably low regardless of ATG dosing (0.12 and 0.21 AU/mL, respectively). The horizontal dashed line at 1 AU/mL is the highest serum/plasma concentration at which T-cells can recover.