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. 2019 Mar 11;6(1):ENEURO.0337-18.2019. doi: 10.1523/ENEURO.0337-18.2019

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Copyright © 2019 Cone et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 2. — PV and SST stimulation impairs, while VIP stimulation improves, contrast increment detection. A, Representative PV mouse behavioral performance from a single contrast increment session. Data are false-alarm corrected performance for trials with (blue) and without (black) activation of PV interneurons as stimulus contrast is varied. Curves are best-fitting Weibull functions that were used to determine detection thresholds (dotted vertical lines) and 95% confidence intervals (solid horizontal lines). B, Summary of PV stimulation effects. Circles depict the contrast increment detection thresholds from individual sessions with (y-axis) and without (x-axis) PV neuron stimulation (five mice, 47 sessions). Filled circles indicate a significant shift in threshold (44/47; bootstrap). C, Representative behavioral performance from a single session in a SST mouse. Same format as A. D, Summary of SST stimulation effects (three mice, 39 sessions; significant threshold difference in 34/39 sessions). Same format as B. E, Representative single session behavioral performance from a VIP mouse. Conventions as in A and C. F, Summary of VIP stimulation effects (three mice 43 sessions; significant threshold difference in 40/43 sessions). Same format as B, D.