Table 2.
KEGG pathways enriched among under and overrepresented proteins upon infection of THP-1 macrophages with R. montanensis.
| ID | Pathway description | Count in gene set | False discovery rate |
|---|---|---|---|
| KEGG PATHWAYS | |||
| R. montanensis-Infected Cells—Proteins With Reduced Abundance | |||
| 3050 | Proteasome | 15 | 4.41E-15 |
| 3040 | Spliceosome | 19 | 2.06E-12 |
| 1200 | Carbon metabolism | 16 | 1.19E-10 |
| 1100 | Metabolic pathways | 48 | 1.90E-09 |
| 10 | Glycolysis/Gluconeogenesis | 11 | 4.39E-08 |
| 30 | Pentose phosphate pathway | 8 | 9.36E-08 |
| 5130 | Pathogenic Escherichia coli infection | 9 | 1.92E-06 |
| 1230 | Biosynthesis of amino acids | 10 | 2.01E-06 |
| 5203 | Viral carcinogenesis | 14 | 1.12E-05 |
| 480 | Glutathione metabolism | 8 | 1.22E-05 |
| 5169 | Epstein-Barr virus infection | 14 | 1.55E-05 |
| 620 | Pyruvate metabolism | 7 | 3.35E-05 |
| 4114 | Oocyte meiosis | 10 | 5.81E-05 |
| R. montanensis-Infected Cells—Proteins With Enriched Abundance | |||
| 3010 | Ribosome | 5 | 0.00773 |
| 4610 | Complement and coagulation cascades | 4 | 0.00773 |
| 5143 | African trypanosomiasis | 3 | 0.013 |
| 510 | N-Glycan biosynthesis | 3 | 0.0238 |
| 5144 | Malaria | 3 | 0.0238 |
| 5150 | Staphylococcus aureus infection | 3 | 0.0238 |
| 5012 | Parkinson's disease | 4 | 0.0344 |
| 4141 | Protein processing in endoplasmic reticulum | 4 | 0.044 |
| 4260 | Cardiac muscle contraction | 3 | 0.044 |
| 4964 | Proximal tubule bicarbonate reclamation | 2 | 0.044 |