Table 4.
Quantified host proteins categorized as mitochondrial transporters and their respective fold change in abundance upon infection of THP-1 macrophages with R. conorii (Rc/uninf) or R. montanensis (Rm/uninf).
| Pathway | Name | UniProt | Log2 (Rc/uninf) | Log2 (Rm/uninf) |
|---|---|---|---|---|
| Mitochondrial transporters | Voltage dependent anion channel 1 (VDAC1) | P21796 | 0.49 | −0.01 |
| Voltage dependent anion channel 2 (VDAC2) | P45880 | 0.37 | 0.02 | |
| Voltage dependent anion channel 3 (VDAC3) | Q9Y277 | 0.42 | 0.10 | |
| Solute carrier family 25 member 1 (SLC25A1) | P53007 | 0.38 | 0.07 | |
| Solute carrier family 25 member 3 (SLC25A3) | Q00325 | 0.66 | 0.14 | |
| Solute carrier family 25 member 5 (SLC25A5) | P05141 | 0.52 | 0.24 | |
| Solute carrier family 25 member 6 (SLC25A6) | P12236 | 0.62 | 0.36 | |
| Solute carrier family 25 member 11 (SLC25A11) | Q02978 | 0.11 | 0.22 | |
| Translocase of outer mitochondrial membrane 22 (TOMM22) | Q9NS69 | 0.55 | 0.29 | |
| Translocase of outer mitochondrial membrane 40 (TOMM40) | O96008 | 0.32 | −0.29 | |
| Mitochondrial carrier 2 (MTCH2) | Q9Y6C9 | 0.41 | 0.14 |
Proteins that are considered as altered (fold change ≤ 0.83 or fold change ≥ 1.2) between infected and uninfected conditions were color-coded according the following: decreased (blue), not changed (transparent) or increased (orange).