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. 2019 Mar 6;9:43. doi: 10.3389/fcimb.2019.00043

Table 5.

Quantified host proteins categorized in proteasome and protein processing in endoplasmic reticulum and their respective fold change in abundance upon infection of THP-1 macrophages with R. conorii (Rc/uninf) or R. montanensis (Rm/uninf).

Pathway Name UniProt EC number Log2 (Rc/uninf) Log2 (Rm/uninf)
Proteasome 26S proteasome non-ATPase regulatory subunit 1 (PSMD1) Q99460 0.04 −0.01
26S proteasome non-ATPase regulatory subunit 2 (PSMD2) Q13200 −0.12 −0.25
26S proteasome non-ATPase regulatory subunit 3 (PSMD3) O43242 0.01 0.02
26S proteasome non-ATPase regulatory subunit 6 (PSMD6) Q15008 0.07 0.06
26S proteasome non-ATPase regulatory subunit 11 (PSMD11) O00231 0.11 0.02
26S proteasome non-ATPase regulatory subunit 12 (PSMD12) O00232 0.22 0.15
26S proteasome non-ATPase regulatory subunit 13 (PSMD13) Q9UNM6 0.06 −0.21
26S proteasome non-ATPase regulatory subunit 14 (PSMD14) O00487 −0.11 −0.07
26S proteasome regulatory subunit 4 (PSMC1) P62191 0.02 −0.04
26S proteasome regulatory subunit 7 (PSMC2) P35998 −0.10 −0.23
26S proteasome regulatory subunit 6A (PSMC3) P17980 −0.25 −0.42
26S proteasome regulatory subunit 6B (PSMC4) P43686 −0.19 −0.45
26S proteasome regulatory subunit 8 (PSMC5) P62195 −0.06 −0.38
26S proteasome regulatory subunit 10B (PSMC6) P62333 −0.13 −0.30
Proteasome subunit alpha type-1 (PSMA1) P25786 3.4.25.1 −0.32 −0.38
Proteasome subunit alpha type-2 (PSMA2) P25787 3.4.25.1 −0.11 −0.09
Proteasome subunit alpha type-3 (PSMA3) P25788 3.4.25.1 −0.23 −0.26
Proteasome subunit alpha type-4 (PSMA4) P25789 3.4.25.1 −0.41 −0.52
Proteasome subunit alpha type-5 (PSMA5) P28066 3.4.25.1 −0.15 −0.34
Proteasome subunit alpha type-6 (PSMA6) P60900 3.4.25.1 −0.23 −0.29
Proteasome subunit alpha type-7 (PSMA7) O14818 3.4.25.1 −0.36 −0.33
Proteasome subunit beta type-1 (PSMB1) P20618 3.4.25.1 −0.37 −0.35
Proteasome subunit beta type-2 (PSMB2) P49721 3.4.25.1 −0.34 −0.34
Proteasome subunit beta type-3 (PSMB3) P49720 3.4.25.1 −0.35 −0.55
Proteasome subunit beta type-6 (PSMB6) P28072 3.4.25.1 −0.24 −0.42
Proteasome subunit beta type-7 (PSMB7) Q99436 3.4.25.1 −0.49 −0.43
Proteasome subunit beta type-8 (PSMB8) P28062 3.4.25.1 −0.01 −0.10
Proteasome activator complex subunit 1 (PSME1) Q06323 −0.42 −0.47
Proteasome activator complex subunit 2 (PSME2) Q9UL46 −0.55 −0.29
Protein processing in endoplasmic reticulum Signal sequence receptor subunit 1 (SSR1) P43307 0.41 −0.05
Signal sequence receptor subunit 4 (SSR4) P51571 0.49 0.19
Dolichyl-diphosphooligosaccharide–protein glycosyltransferase non-catalytic subunit (DDOST) P39656 0.44 0.03
STT3A, catalytic subunit of the oligosaccharyltransferase complex (STT3A) P46977 2.4.99.18 0.65 0.30
STT3B, catalytic subunit of the oligosaccharyltransferase complex (STT3B) Q8TCJ2 2.4.99.18 0.72 0.34
Ribophorin I (RPN1) P04843 0.45 0.04
Ribophorin II (RPN2) P04844 0.51 0.35
Heat shock protein family A (Hsp70) member 5 (HSPA5) P11021 0.57 −0.02
Calnexin (CANX) P27824 0.70 0.14
Calreticulin (CALR) P27797 0.47 0.00
Hypoxia up-regulated 1 (HYOU1) Q9Y4L1 0.64 0.29
DnaJ heat shock protein family (Hsp40) member B11 (DNAJB11) Q9UBS4 0.38 −0.19
Heat shock protein family A (Hsp70) member 8 (HSPA8) P11142 −0.21 −0.12
Heat shock protein 90 alpha family class A member 1 (HSP90AA1) P07900 −0.21 −0.26
Heat shock protein 90 beta family member 1 (HSP90B1) P14625 0.56 0.00
Heat shock protein 90 alpha family class B member 1 (HSP90AB1) P08238 0.14 0.09
Heat shock protein family H (Hsp110) member 1 (HSPH1) Q92598 0.34 −0.04
Protein disulfide isomerase family A member 3 (PDIA3) P30101 5.3.4.1 0.32 0.03
Protein disulfide isomerase family A member 4 (PDIA4) P13667 5.3.4.1 0.46 0.04
Protein disulfide isomerase family A member 6 (PDIA6) Q15084 5.3.4.1 0.49 0.00
UDP-glucose glycoprotein glucosyltransferase 1 (UGGT1) Q9NYU2 2.4.1. 0.43 0.03
Glucosidase II alpha subunit (GANAB) Q14697 3.2.1.84 0.43 0.14
Protein kinase C substrate 80K-H (PRKCSH) P14314 0.38 −0.07
Lectin, mannose binding 1 (LMAN1) P49257 0.26 0.10
Lectin, mannose binding 2 (LMAN2) Q12907 0.33 0.01
SEC13 homolog, nuclear pore and COPII coat complex component (SEC13) P55735 0.08 −0.06
SEC63 homolog, protein translocation regulator (SEC63) Q9UGP8 0.60 0.19
Valosin containing protein (VCP) P55072 −0.06 −0.13
Eukaryotic translation initiation factor 2 subunit alpha (EIF2S1) P05198 −0.17 −0.35

Proteins that are considered as altered (fold change ≤ 0.83 or fold change ≥ 1.2) between infected and uninfected conditions were color-coded according the following: decreased (blue), not changed (transparent) or increased (orange).