Table 3.
Examination of sex differences in imaging target in the context of former treatment time windows and NIHSS criteria
| Selection scenario | Within window | OR P‐values | Beyond window | OR P‐values | n | ||||
|---|---|---|---|---|---|---|---|---|---|
| Men (% targets) | Women (% targets) | Sex OR (W/M) | Men (% targets) | Women (% targets) | Sex OR (W/M) | ||||
| iv TPA (0–4.5 h window) | |||||||||
| Perfusion target | 150/195 (76.9%) | 223/267 (83.5%) | 1.52 | 0.08 | 135/200 (67.5%) | 162/220 (73.6%) | 1.34 | 0.168 | 882 |
| Any arterial target | 115/228 (50.4%) | 195/310 (62.9%) | 1.67 | 0.00 | 95/214 (44.4%) | 141/259 (54.4%) | 1.50 | 0.03 | 1,011 |
| TPA OCCLUSION | 76/228 (33.3%) | 132/310 (42.6%) | 1.48 | 0.03 | 135/200 (67.5%) | 162/220 (73.6%) | 1.34 | 0.168 | 1,011 |
| EVT OCCLUSION | 51/228 (22.4%) | 103/310 (33.2%) | 1.73 | 0.01 | 41/214 (19.2%) | 54/259 (20.8%) | 1.11 | 0.648 | 1,011 |
| Perfusion‐diffusion mismatch | 101/195 (51.8%) | 160/267 (59.9%) | 1.39 | 0.08 | 76/200 (38.0%) | 96/219 (43.8%) | 1.27 | 0.226 | 881 |
| Guideline EVT (0–6 h window); limited to ICA and M1 occlusions & NIHSS ≥6 | |||||||||
| Perfusion target | 42/42 (100%) | 86/92 (93.5%) | 0.00 | 0.09 | 21/28 (75.0%) | 30/34 (88.2%) | 2.50 | 0.178 | 196 |
| Perfusion‐diffusion mismatch | 36/42 (85.7%) | 73/92 (79.4%) | 0.64 | 0.38 | 19/28 (67.9%) | 23/34 (67.7%) | 0.99 | 0.986 | 196 |
| Extended window EVT (6–24 h window); limited to ICA and M1 occlusions & NIHSS ≥10 | |||||||||
| Perfusion‐diffusion mismatch | 32/38 (84.2%) | 59/72 (81.9%) | 0.85 | 0.77 | 16/20 (80.0%) | 18/26 (69.2%) | 0.56 | 0.415 | 156 |