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. 2019 Feb 27;6(3):537–545. doi: 10.1002/acn3.726

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© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Results of multivariate ROC analysis. ROC analysis plots for pairwise comparison based on CDR values using age and significant metabolite levels. Results for the combination of age and individual metabolites are shown in the top row. The bottom row contains plots obtained after adding Cit/Arg and Kyn/Trp ratio biomarkers. The curves show the best delimitation of AUC for each combination. Designation 0 versus non‐0 refers to CDR and indicates the power of that particular marker combination to discriminate normal controls from other participants. Similarly, 0 versus 0.5 refers to discrimination of normal controls from MCI patients (0.5 vs. 1, discrimination between MCI and AD; 1 vs. non‐1, discrimination between AD and non‐AD participants).