Comparison 2. Mediterranean dietary intervention versus another dietary intervention for primary prevention.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Composite clinical events (CVD death, stroke, MI)	1	7447	Hazard Ratio (Random, 95% CI)	0.70 [0.58, 0.85]
2 CVD mortality	1	7447	Hazard Ratio (Random, 95% CI)	0.81 [0.50, 1.32]
3 Total mortality	1	7447	Hazard Ratio (Random, 95% CI)	1.00 [0.81, 1.24]
4 Myocardial infarction	1	7447	Hazard Ratio (Random, 95% CI)	0.79 [0.57, 1.10]
5 Stroke	1	7447	Hazard Ratio (Random, 95% CI)	0.60 [0.45, 0.80]
6 Peripheral arterial disease	1	7447	Hazard Ratio (Random, 95% CI)	0.42 [0.28, 0.61]
7 Incidence type 2 diabetes	1	3541	Hazard Ratio (Random, 95% CI)	0.71 [0.52, 0.96]
8 Stroke (unadjusted)	1	180	Risk Ratio (M‐H, Random, 95% CI)	0.33 [0.04, 3.14]
9 Total cholesterol (mmol/L), change from baseline	7	939	Mean Difference (IV, Random, 95% CI)	‐0.13 [‐0.30, 0.04]
10 LDL cholesterol (mmol/L), change from baseline	7	947	Mean Difference (IV, Random, 95% CI)	‐0.15 [‐0.27, ‐0.02]
11 HDL cholesterol (mmol/L), change from baseline	6	891	Mean Difference (IV, Random, 95% CI)	0.02 [‐0.01, 0.04]
12 Triglycerides (mmol/L), change from baseline	7	939	Mean Difference (IV, Random, 95% CI)	‐0.09 [‐0.16, ‐0.01]
13 Systolic blood pressure (mmHg), change from baseline	4	448	Mean Difference (IV, Random, 95% CI)	‐1.50 [‐3.92, 0.92]
14 Diastolic blood pressure (mmHg), change from baseline	4	448	Mean Difference (IV, Random, 95% CI)	‐0.26 [‐2.41, 1.90]