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. 2019 Mar 12;9:4200. doi: 10.1038/s41598-019-41061-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pancreatic islet structures of HNF4α^ΔIEC mice. (A) Representative immunofluorescence of insulin and glucagon on two distinct islets of Langerhans sections obtained from adult control and HNF4α^ΔIEC mice. Computed image analysis using CellProfiler (3.1.5) was designed to quantify labeled cells. Representative image analysis obtained from HNF4α^ΔIEC mice islet sections (bottom panel) highlights positive detected cells (colored nuclei), overlapping immunofluorescence (white diffuse staining) and non-labeled islet cells (empty and white circled nuclei). (B) Pancreatic islets area measured in adult control (black column) and HNF4α^ΔIEC (white column) mice (n = 4–5). (C) Relative population of cells positive for insulin (green columns) or glucagon (red columns) signals in pancreatic islets of adult control and HNF4α^ΔIEC mice (n = 3–5).