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. 2019 Mar 12;9:4200. doi: 10.1038/s41598-019-41061-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hormonal and glycemic response in HNF4α^ΔIEC mice. Circulating GIP (A), GLP-1 (B) and insulin (C) levels measured by ELISA in control (black squares) and HNF4α^ΔIEC (blue squares) mice following an oral glucose tolerance test (OGTT) (n = 4–10). (D) Blood glucose measured in control (black squares) and HNF4α^ΔIEC (blue squares) mice during OGTT (n = 4 = 10). (E) Insulinogenic index was calculated in control (black columns) and HNF4α^ΔIEC (white columns) mice as follows: Δinsulin peak/Δblood glucose peak, where Δ is the time point concentration minus baseline level (n = 6–7). (F) Blood glucose measured in control (black squares) and HNF4α^ΔIEC (blue squares) mice during an intraperitoneal glucose tolerance test (IPGTT) (n = 7–9). (G) Insulin tolerance test (ITT) performed on control (black squares) and HNF4α^ΔIEC (blue squares) mice (n = 6–11).