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. 2019 Mar 12;9:4200. doi: 10.1038/s41598-019-41061-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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White adipocyte tissue density and body composition in HNF4α^ΔIEC mice. (A) Ranging of adipocytes according to their size as quantified by CellProfiler (3.1.5) from white adipose tissue sections from adult control (black squares) and HNF4α^ΔIEC (blue squares) mice (n = 7–8). The AUC calculated from control (black columns) and HNF4α^ΔIEC (white columns) mice (n = 7–8) is represented in (B). Dual-energy X-ray absorptiometry (DXA) measurements for body composition were acquired post-mortem from 4-month-old and 7-month-old mice. (C) Fat tissues (light yellow) and lean tissues (dark orange) are shown relative to total body weight of control (dark bordered squares) and HNF4α^ΔIEC (hatched squares) mice (n = 8–13). Osteodensitometry measurements for bone area (D), bone mineral content (BMC) (E) and bone mineral density (BMD) (F) of control (black columns) and HNF4α^ΔIEC (white columns) mice were calculated from DXA analysis (n = 8–13).