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. 2019 Mar 12;10:951. doi: 10.1038/s41467-019-08721-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Splenic T and B cells demonstrate induction of genes following US treatment. The dot plot displays the statistically significantly differentially expressed genes (DEGs) in T cells (top list) and B cells (bottom list) from mice given arthritogenic serum comparing US versus sham-US stimulation. The size of each circle represents the percent of cells within each cell type (T cells = T, B cells = B) which express the gene listed, and the color of each circle represents average scaled expression. Gray bars denote mouse treatment groups; genes that are in bold are statistically significantly DEG in both T cells and B cells, and genes found to also be DEG in non-arthritic mice with US stimulation (see Supplementary Fig. 8) are denoted with a superscript x. Adjusted p-values for each gene in either T or B cells (top or bottom gene lists) are shown in shades of green. All DEGs listed in this Figure range in statistical significance from p = 2.39e-02 to p = 3.95e-230 using a Wilcox rank sum test with Bonferroni correction