Fig. 4.

Splenic U/S stimulation suppresses systemic TNF levels during endotoxemia through CAP. a Splenic concentrations of TNF are shown for sham controls (LPS, -U/S) and U/S stimulated mice (0.83 MPa ultrasound setting) for C57black/6 mice, Nude mice, CD4 ChAT knock-out mice, and α7nAChR knock-out mice. b Serum TNF concentrations are shown for sham controls (LPS, -U/S) and U/S stimulated mice (0.83 MPa) ultrasound setting for saline injection controls and reserpine treated/denervated (see Methods for details) mice. All experiments in this figure were performed using the same U/S settings as in Figs. 2 and 3 (0.83 MPa)