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. 2019 Mar 12;9:4188. doi: 10.1038/s41598-019-40786-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proteomics of BCP-ALL relapse. (a) The heatmap shows the proteins that are significantly up-regulated at REL. Proteins of the Phosphate Pentose pathway (PPP) and Glycolysis pathway, both overrepresented pathways at REL, are indicated at the right side of the heatmap by a P or G, respectively. The heatmap has been hierarchically clustered (top and right side representations in grey) using Gitools⁵⁸. (b) Shows expression change of four metabolic proteins at ID and REL. If the net increase in expression is positive, the line is shown in red, otherwise in blue. (c) The box plots show protein expression levels of the members of the PPP as presented in the heatmap in (a), itemized by TP53 wild type (wt; n = 44) and TP53 sequence mutations (mut; n = 7). The significances are represented by the stars next to the protein name as follows: 1 star (*): 0.05 ≥ p > 0.01, 2 stars (**): 0.01 ≥ p > 0.001.