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. 2019 Mar 12;9:4232. doi: 10.1038/s41598-019-40324-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Absence of TNFR1 increased tissue injury in the Mdr2^−/− mouse model. (A) ALT and (B) ALP levels determined in plasma of WT (n ≥ 4), Tnfr1^−/− (n ≥ 6), Mdr2^−/− (n ≥ 9), and Tnfr1^−/−/Mdr2^−/− (n ≥ 9) mice. (C) Quantification of the hepatic hydroxyproline content of mice described in A. (D) Relative hepatic expression of Acta2, Col1a1, Col3a1, Mmp2, Mmp9, Timp1, and Timp2 of mice described in A, determined by RT-qPCR. (E) Representative images (10x) of Sirius Red stained tissue sections of mice described in (A). *P ≤ 0.05, ***P ≤ 0.001, ****P ≤ 0.0001.