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. 2019 Mar 12;9:4269. doi: 10.1038/s41598-019-38905-z

Figure 3.

Figure 3

MHV68-EGFP infection leads to widespread intra-insulitis in young Avy/MIP-TF mice. (A) Avy/MIP-TF mice were infected at 10–12 weeks in age with wildtype MHV68 or MHV68-EGFP and twenty one days later their pancreata were examined for infiltrates. Eighty islets were scored from each animal. Bars show mean insulitis score in WT-MHV68 infected (open bar, n = 4) and MHV68-EGFP (black bar, n = 9) infected Avy/MIP-TF mice ± SEM, *p = 0.05). MHV68-EGFP infected Avy/MIP-TF mice also had significantly higher insulitis score than MHV68-EGFP infected MIP-TF mice (see Fig. 2, p < 0.01). Insulitis in control uninfected Avy/MIP-TF mouse pancreata was at base-line (not shown). Represenataive image of a WT-MHV68 infected (B) and MHV68-EGFP-infected (C) Avy/MIP-TF mouse pancreas section stained with H&E. Mononuclear cell infiltrates are circled in yellow. (D) Anti-CD3, (E) Anti-B220, and (F) Mac1 stained MHV68-EGFP-infected Avy/MIP-TF mouse pancreas sections.