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. 2019 Mar 12;9:4269. doi: 10.1038/s41598-019-38905-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Th1-type autoimmunity spreads from EGFP to other β-cell antigens in obese, but not lean, MHV68-EGFP-infected mice. MIP-TF and A^vy/MIP-TF mouse littermates were infected with MHV68-EGFP and 21 days later the frequency of antigen-specific IFNγ-secreting splenic T cell responses from individual mice was determined by ELISPOT assay. Data are expressed as mean IFN_γ-secreting spot forming colonies (SFC) per million mononuclear cells ± SEM. N = 5 mice/group. The frequency of IFNγ-secreting SFC in response to control muscle homogenate (by both MIP-TF and A^VY/MIP-TF spleen cells) and to GAD65 by MIP-TF spleen cells were near to the base-line. Splenic cells cultured at medium alone resulted in ≤5 SFC. **p < 0.01.