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. 2019 Mar 12;9:4291. doi: 10.1038/s41598-019-39678-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Local wounds can manipulate cell migration. (A) Typical trajectory of cell migration after being subjected to repeated multiple local wounding. Laserporation was applied for five times at the anterior regions of the migrating cell. Yellow line represents the trajectory of cell centroid. Five bright field images are shown when the laserporation was applied (white spots). Red arrows indicate the positions in the trajectory after cell wounding. Green arrows indicate the direction of cell migration. The direction of movement changed each time the cell was wounded. (B) In the aggregation stream, laserporation was applied at the anterior region of a single cell (white spot). The wounded cell (outlined with white line) migrated in the opposite direction after wounding. Note that other cells migrated towards the right direction (black arrow). Bar, 10 µm.