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. 2019 Mar 12;9:4165. doi: 10.1038/s41598-019-40729-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TreeMap visualization of biological process GO terms (small rectangles) up-regulated. In REVIGO. Superclusters of loosely related terms are visualized using different colors. The size of each rectangle reflects the p-value of the GO term. Where 1. Central nervous system development; 2. Regulation of neuron migration; 3. Neuromuscular process; 4. Neuromuscular process controlling balance; 5. Nerve development; 6. Embryonic camera-type eye morphogenesis; 7. Glomerulus development; 8. Post-embryonic development; 9. Gland morphogenesis; 10. Artery development; 11. Neuroepithelial cell differentiation; 12. Embryonic pattern specification; 13. Developmental growth involved in morphogenesis; 14. Neural tube closure; 15. Head development; 16. Cranial nerve development; 17. Cell morphogenesis; 18. Peripheral nervous system development; 19. Autonomic nervous system development; 20. Neural precursor cell proliferation; 21. Synapse organization; 22. Regulation of synapse structure or activity; 23. Plasma membrane organization; 24. Regulation of cell size; 25. Regulation of small GTPase mediated signal transduction; 26. Positive regulation of JUN kinase activity; 27. Negative chemotaxis; 28.Posttranscriptional gene silencing by RNA; 29. Steroid hormone mediated signaling pathway; 30. Regulation of glutamate receptor signaling pathway; 31. Regulation of synaptic plasticity; 32. Negative regulation of translation; 33. Semaphorin-plexin signaling pathway; 34. Locomotory behavior.