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. 2019 Mar 12;10(2):e00066-19. doi: 10.1128/mBio.00066-19

FIG 4.

FIG 4

In vivo prophylactic and therapeutic activity of the IBV hMAbs. (A) Prophylactic activity. Female C57BL/6 mice (n = 3 per group/time point) were administered the indicated IBV NA hMAbs at 20 mg/kg i.p. or the irrelevant isotype control (IC) 1069 D6 hMAb at 20 mg/kg i.p. At 6 h after dosing, mice were inoculated i.n. with 1 × 106 FFU B/Brisbane/60/2008. (B) Therapeutic activity. Female C57BL/6 mice (n = 3 per group) were inoculated i.n. with 1 × 106 FFU B/Brisbane/60/2008 and 24 h later were administered the indicated IBV NA hMAb or the irrelevant isotype control (IC) 1069 D6 hMAb at 20 mg/kg i.p. Viral replication (A and B) was determined by measuring viral titers in the lungs of the infected mice at 2 and 4 days p.i. (dpi). Each symbol represents an individual mouse. The “&” symbol indicates that virus was detected in only one or two mice per group. “f” indicates that virus was not detected in any mouse in the group. *, P < 0.05 (using one-way ANOVA with multiple-outcome correction).