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. 2019 Mar 12;10(2):e02790-18. doi: 10.1128/mBio.02790-18

TABLE 2.

Antimicrobial resistance housekeeping genes used to search C. difficile whole-genome sequences

Housekeeping
gene		 Nonsynonymous
substitution		 Protein
modified		 Antimicrobial resistance
phenotype
gyrAa T(82)I DNA gyrase subunit A Fluoroquinolones
gyrBa D(426)N DNA gyrase subunit B Fluoroquinolones
rpoBb R(505)K β subunit RNA polymerase Rifampicin
a

Resistance to fluoroquinolones in C. difficile can be accurately predicted by the presence of the nonsynonymous mutations in the following genes: gyrA C(245)T [T(82)I] and gyrB G(1276)A and [D(426)N] (8 [Table S1], 81–83).

b

The R(505)K substitution is the most frequently identified single substitution resulting in high-level (>32 mg/liter) resistance to rifampin (83, 84).