FIG 4.

Coabundance groups of all the key OTUs in mice. (A) OTU-level network diagram of 146 key OTUs responding to the effects of CTX and different diet. The size of the node indicates the mean abundance of each OTU. Lines between nodes represent correlations between the nodes they connect, with the line width indicating correlation magnitude and color for correlation (red for a negative correlation, gray for a positive correlation). Only lines corresponding to correlations with a magnitude greater than 0.5 are drawn. OTUs are grouped into 22 CAGs by permutation multivariate analysis of variance (PERMANOVA) when P < 0.05. (B) Heat map of the FDR value for CAGs, indicating the changes induced by diet or CTX stress. The tests of significance were performed using a two-sided Mann-Whitney test, and the calculation of FDR was performed using the procedure originally introduced by Benjamini and Hochberg.