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The mRNA nuclear export pathway. The bulk of mRNA is exported into the cytoplasm by the TREX:NXF1 pathway. During transcription initial TREX complex members are deposited upon the mRNA. Further processing such as capping and splicing results in further TREX deposition. Once an mRNA has matured the export receptor NXF1 associates with the mRNA via TREX complex interactions. NXF1 guides the correctly packaged mRNA through the nuclear pore.
