Table 2.
Conservation of amino acid residues at positions 28 and 65 in PA-X among different virus subtypes.
| Virus | Host | Amino acid at the indicated position |
|
|---|---|---|---|
| 28 | 65 | ||
| H1N1pre09 | Human | L (98.2%a) | P (85.7%) |
| H1N1pdm09 | Human | P (91.9%) | S (91.9%) |
| H1N1 | Avian | P (99.7%) | S (98.8%) |
| H3N2 | Human | L (99.9%) | L (99.9%) |
| Avian | P (97.6%) | S (100%) | |
| H5N1 | Human | P (100%) | S (98.9%) |
| Avian | P (99.5%) | S (99.7%) | |
| H7N9 | Human | P (100%) | S (100%) |
| Avian | P (99.8%) | S (99.8%) | |
aPercentage of isolates with the indicated residue isolated from each host. Virus isolates deposited in the Influenza Research Database as of October 2017 (1,181 human isolates of H1N1pre09, 998 human isolates of H1N1pdm09, 635 avian isolates of H1N1, 1,150 human and 375 avian isolates of H3N2, 270 human and 731 avian isolates of H5N1, and 110 human and 641 avian isolates of H7N9) were analyzed.