Scheme 1.
(A) Polyplex formation of P(Lys)-b-P(HPMA)-N3(stat) or P(Lys)-b-P(HPMA)-N3(end) block copolymers with pDNA. (B) Strain-promoted alkyne-azide cycloaddition (SPAAC) of azide-functionalized polyplex and DBCO-modified aDEC205.
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