Table 6.
Composition of oral lyophilisates containing CP loaded IPECs formed by NAA-1 and EPO in the ratio 33:67 %. The amount of IPEC was defined in order to have 120 μg drug per unit. The main features of CP loaded IPECs after disintegration were evaluated in terms of particle size (Dh) and zeta-potential (ζ).
| Formulation | Tablet Composition (%w/w) | Dh | Disintegration | |||||
|---|---|---|---|---|---|---|---|---|
| Composition | IPEC | Span®80 | DS | Time (s) | Dh (nm) | ζ (mV) | ||
| 1 | CP-IPEC 50:50 | 0.29 | 1.20 | 98.50 | 299 ± 122 (95.6%) | <30 | 323 ± 69 | 1.08 ± 0.16 |
| 2 | CP-IPEC 60:40 | 0.24 | 1.21 | 98.55 | 419 ± 81 | <30 | 363 ± 122 | −0.99 ± 1.25 |
| 3 | CP-IPEC 70:30 | 0.21 | 1.21 | 98.59 | 306 ± 198 | <30 | 350 ± 87 | −4.42 ± 0.46 |
| 4 | CP-IPEC 80:20 | 0.18 | 1.21 | 98.61 | 369 ± 178 | <30 | 448 ± 122 | −2.90 ± 1.64 |
| 5 | CP-IPEC 90:10 | 0.16 | 1.21 | 98.63 | 518 ± 88 | <30 | 356 ± 70 | 3.27 ± 0.60 |