. 2018 Feb 26;10(3):235. doi: 10.3390/polym10030235

Table 4.

Hydrophobically modified chitosan and chitosan oligosaccharides.

Hydrophobic moiety	Active agent	Particle size (nm)	Zeta-potential (mV)	Ref.
deoxycholic acid	DNA	162 ± 18 ^a		[145]
		~300 ^b
		130–300 ^a		[146]
cholesterol	Epirubicin	417 ± 18 ^a		[147]
cholesterol	Epirubicin	338–473 ^b		[147]
6-O-cholesterol	All-trans retinoic acid	100–240 ^a	+24.5 to +25.9 ^a	[148]
6-O-cholesterol	All-trans retinoic acid	192–222 ^b	+24.5 to +25.9 ^a
stearyl	Paclitaxel	28.1–74.6 ^a	+39.0 to +53.2 ^a	[149]
stearyl		35.8–175.1 ^b	+44.0 to +58.7 ^b
	Doxorubicin	272–322 ^a	+34.2 to +57.1 ^a	[150]
		305–355 ^b	+51.8 to +69.1 ^b
		27.4 ± 2.4 ^a	+52 ± 3 ^a	[151]
		20.4 ± 1.1 ^b	+53.1 ± 14.4 ^b
stearyl + doxorubicin	Doxorubicin	40.1–105.8 ^b	+32.0 to +43.7 ^b	[152]
Acyl	Rifampin	154–181 ^a		[153]
Acyl		163–210 ^b
	Vitamin C	444–487 ^a	+10.2 to +28.9 ^a	[154]
	Vitamin C	216–288 ^b	+5.9 to +18.4 ^b	[154]
N,O6-acetyl + steroid	Steroids	197–358 ^b	+7 to +22.7 ^b	[155]
N,O6-acetyl + tocopherol	Vitamin E	275 ± 5 ^b	+14.9 ± 0.7 ^b	[155]
phthaloyl	Camptothecin	~170 ^a		[156]
	Camptothecin	~200–267 ^b
		~50–100 ^a
		~100–250 ^b		[157]
	All-trans retinoic acidPrednisone acetate	~50–100 ^a		[158,159]
		~80–160 ^b
		89.8 ^a
		143.3 ^b
polycaprolactone, (Chitosan-grafted)	7-Ethyl-10-hydroxy-camptothecin	47–113 ^a	+26.7 to +50.8 ^a	[160]
polycaprolactone, (Chitosan-grafted)	7-Ethyl-10-hydroxy-camptothecin	63–152 ^b	+25.6 to +48.8 ^b	[160]
	BSA	168.44 ^b		[161]
		200.7 ^b
		435 ± 25 ^a
	Paclitaxel	408–529 ^b	+27.5 ± 1.1 ^a	[162]
	Paclitaxel	61.4–108.6 ^a	+30.9 to +33.3 ^b
	5-Fluorouracil	67.9–96.7 ^b	+18.9 to +43.1 ^b	[163]
N-acetyl histidine	Doxorubicin	218 ^a	+40.1 ± 2.8 ^a	[164]
N-acetyl histidine	Doxorubicin	185.3–218.3 ^b	+36.3 to +40.1 ^b	[164]

^a Unloaded particle; ^b loaded particle; * 5 mg/mL.