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In vivo antitumor effect of BLM-loaded liposomes. Free BLM, BLM-Lipo, or BLM-pHLipo was administered intravenously to Colon-26 tumor-bearing BALB/c mice. Changes in (a) tumor volume (mm3) and (b) body weight were monitored (n = 6). Control vs. BLM-pHLipo (1 mg/kg): p = 0.001; Control vs. BLM-pHLipo (5 mg/kg): p = 0.023; BLM-Lipo (10 mg/kg) vs. BLM-pHLipo (1 mg/kg): p = 0.013; Friedman test.
