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. 2019 Mar 13;2019(3):CD012279. doi: 10.1002/14651858.CD012279.pub2
Study Reason for exclusion
Adel 2013 Wrong study design
Alves 2014 Wrong intervention
Alves 2014a Wrong intervention
Anderson 2014 Intervention shorter than 12 weeks: 8‐week intervention period (2‐arm trial; n = 67; likely cognitive healthy; mean age 63 years; extension of earlier trial)
Ann 2012 Wrong patient population
Apostolo 2014 Wrong patient population
Baglio 2011 Nature of intervention unclear
Ball 2002 Intervention shorter than 12 weeks: 5‐ to 6‐week intervention period with 2‐ to 3‐week booster period at 11 and 35 months (4‐arm trial ACTIVE; n = 2832; cognitively healthy; mean age 74 years)
Ball 2002a Duplicate
Ball 2006 Intervention shorter than 12 weeks. Multiple reports for excluded trial: Ball 2002 (trial ACTIVE)
Ball 2013 Intervention shorter than 12 weeks
Ballesteros 2014 Duplicate
Ballesteros 2014a Duplicate
Ballesteros 2015 Duplicate
Ballesteros 2015a Duplicate
Ballesteros 2017 Intervention shorter than 12 weeks
Bamidis 2015 Wrong study design
Baniqued 2014 Adult population
Baniqued 2015 Younger than 30 years of age
Barban 2012 Duplicate
Barban 2016 Wrong study design
Barbosa 2015 Wrong intervention
Barcelos 2015 Wrong intervention
Barnes 2006 Intervention shorter than 12 weeks
Barnes 2009 Duplicate
Basak 2016 Intervention shorter than 12 weeks: 2 week intervention period (2‐arm trial; n = 46; cognitively healthy; mean age 69 years)
Beck 2013 Wrong intervention
Belchior 2007 Wrong outcomes
Belchior 2008 Wrong outcomes
Belleville 2006 Wrong intervention
Belleville 2014 Wrong outcomes
Berry 2010 Intervention shorter than 12 weeks: 3 to 5 weeks (2‐arm trial: n = 32; cognitively healthy; mean age 72 years)
Bier 2015 Wrong study design
Binder 2016 Intervention shorter than 12 weeks
Bittner 2013 Wrong study design
Borella 2010 Intervention shorter than 12 weeks: 2 weeks (2‐arm trial; n = 40; cognitively healthy; mean age 69 years)
Borella 2013 Wrong intervention
Borella 2014 Duplicate
Borella 2017 Wrong intervention
Boripuntakul 2012 Wrong intervention
Borness 2013 Wrong patient population
Bottiroli 2009 Duplicate
Bottiroli 2009a Intervention shorter than 12 weeks: 3 training sessions (2‐arm trial; n = 44; cognitively healthy; mean age 66 years)
Bozoki 2013 Intervention shorter than 12 weeks: 6‐week intervention period (2‐arm trial; n = 60; cognitively healthy; mean age 69 years)
Brehmer 2012 Intervention shorter than 12 weeks: 5‐week intervention period (2‐arm trial stratified by younger and older age groups; n = 45 in old age groups, n = 55 in young age groups; cognitively healthy; mean age 64 years in old age groups, 26 in young age groups)
Brum 2013 Duplicate
Buitenweg 2017 Wrong intervention
Buiza 2008 Wrong intervention
Bureš 2016 Intervention shorter than 12 weeks
Buschert 2011 Wrong intervention
Buschert 2011a Duplicate
Buschert 2012 Wrong intervention
Buschert 2012a Duplicate
Calkins 2011 Wrong intervention
Cammarata 2011 No outcome given
Cancela 2015 Wrong patient population
Candela 2015 Wrong intervention
Cantarella 2017 Intervention shorter than 12 weeks
Cao 2016 Wrong route of administration
Carretti 2013 Wrong intervention
Casutt 2014 Wrong outcomes
Chapman 2015 Wrong intervention
Chapman 2016 Wrong intervention
Chapman 2017 Wrong intervention
Cheng 2012 Wrong intervention
Cheng 2018 Wrong patient population
Cho 2002 Younger than 30 years of age
Cleverley 2012 Wrong intervention
Cohen‐Mansfield 2014 Wrong intervention
Cohen‐Mansfield 2014a Wrong intervention
Cohen‐Mansfield 2015 Wrong intervention
Cohen‐Mansfield 2015a Duplicate
Combourieu 2014 Wrong outcomes
Corbett 2015 Wrong patient population
Costa 2015 Wrong patient population
Danassi 2015 Duplicate
Dannhauser 2014 Wrong study design
de Almondes 2017 Intervention shorter than 12 weeks
de Macedo 2015 Wrong outcomes
De Vreese 1996 Wrong intervention
Desjardins‐Crépeau 2016 Wrong patient population
Diamond 2015 Intervention shorter than 12 weeks: 7‐week intervention period (2‐arm trial; n = 64; cognitively healthy; mean age 66 years)
Dittmann‐Kohli 1991 Wrong intervention
Duncan 2009 Wrong intervention
Dwolatzky 2005 Intervention shorter than 12 weeks: multiple reports for excluded trial: Wolinsky 2015 (IHAMS study). This citation refers to the trial registration NCT01165463
Eckroth‐Bucher 2009 Wrong patient population
Edwards 2005 Intervention shorter than 12 weeks: maximum 12 sessions (2‐arm SKILL trial; n = 126; participants with initial processing speed or processing difficulty; mean age 76 years)
Edwards 2011 Intervention shorter than 12 weeks: multiple reports for Edwards 2005 (SKILL trial)
Edwards 2015 Intervention shorter than 12 weeks: planned treatment duration 10 to 12 weeks, but less than 12 weeks provided on average
Edwards 2015a Duplicate
Efthymiou 2011 Wrong comparator.
Engvig 2014 Wrong study design
Fabre 2002 Wrong intervention
Faille 2007 Nature of intervention unclear
Fairchild 2010 Wrong intervention
Feng 2013 Wrong intervention
Feng 2015 Wrong intervention
Feng 2017 Wrong patient population
Finn 2011 Intervention shorter than 12 weeks
Finn 2015 Intervention shorter than 12 weeks: 4‐week intervention period (2‐arm trial; n = 41; participants with MCI; mean age 75 years)
Finn 2015a Duplicate
Flak 2013 Study protocol
Flak 2014 Study protocol
Flak 2014a Study protocol
Flak 2016 Study protocol
Foerster 2009 No outcome given
Forloni 2012 No outcome given
Forster 2011 Wrong intervention
Fortman 2013 Wrong comparator
Gagnon 2012 Wrong study design
Gagnon 2012a Intervention shorter than 12 weeks: 2‐week intervention period (2‐arm trial; n = 24; participants with MCI; mean age 68 years)
Gaitan 2013 Wrong patient population
Gajewski 2012 Intervention shorter than 12 weeks: cognitive training over 16 weeks, of which 12 concerned computerised cognitive training (4‐arm trial; n = 141; cognitively healthy; mean age 71 years)
Gajewski 2017 Intervention shorter than 12 weeks
Garcia‐Campuzano 2013 Nature of intervention unclear
Gates 2011 Study protocol
Gill 2016 Wrong intervention
Gillette 2009 No outcome given
Giovannini 2015 No outcome given
Giuli 2016 Wrong intervention
Giuli 2017 Wrong intervention
Golino 2017 Wrong intervention
Haesner 2015 Wrong study design
Haesner 2015a Intervention shorter than 12 weeks: 8‐week intervention (2‐arm trial; n = 80, 40 cognitively healthy and 40 with subjective memory complaints; mean age 70 years)
Haimov 2013 Duplicate
Haimov 2013a Duplicate
Haimov 2013b Intervention shorter than 12 weeks: 8‐week intervention period (2‐arm study; n = 51; likely cognitively healthy; mean age 72 years)
Haimov 2013c Duplicate
Haimov 2013d Intervention shorter than 12 weeks: multiple reports for Haimov 2013b
Haimov 2014 Intervention shorter than 12 weeks: multiple reports for Haimov 2013b
Haimov 2014a Intervention shorter than 12 weeks: multiple reports for Haimov 2013b
Hardy 2015 Intervention shorter than 12 weeks: 10‐week intervention period (2‐arm trial; n = 9919; cognitively healthy; mean age 39 years; subgroup data by age can be analysed)
Hausmann 2012 Wrong intervention
Hayashi 2012 Wrong intervention
Hayslip B Jr 2016 Intervention shorter than 12 weeks
Heinzel 2014 Intervention shorter than 12 weeks: 4‐week intervention period (2‐arm trial; n = 60; 2‐arm trial stratified by younger and older age groups; n = 30 in old age groups, n = 30 in young age groups; cognitively healthy; mean age 66 years in old age groups, 26 in young age groups)
Hudak 2013 Intervention shorter than 12 weeks: 10‐week intervention period (3‐arm trial; n = 53; cognitively healthy; mean age 82 years)
Hötting 2013 Intervention shorter than 12 weeks: 6 sessions during 1 month (4‐arm trial; n = 33; cognitively healthy; mean age 49 years)
Ignjatovic 2015 Younger than 30 years of age
Irigaray 2012 Wrong intervention
Israel 1997 Nature of intervention unclear
ISRCTN70130279 Wrong intervention
Jackson 2012 Nature of intervention unclear
Jansen 2012 Wrong intervention
Jean 2010 Intervention shorter than 12 weeks: 3‐week intervention period (2‐arm trial; n = 22; participants with MCI; mean age 69 years)
Jeong 2016 Wrong intervention
Jobe 2001 Intervention shorter than 12 weeks: multiple reports for excluded trial: Ball 2002 (trial ACTIVE)
Jones 2013 Intervention shorter than 12 weeks: multiple reports for Ball 2002 (trial ACTIVE)
Kampanaros 2010 Wrong intervention
Kholin 2010 Intervention shorter than 12 weeks: 30‐day intervention period (2‐arm trial; n = 60; participants with MCI; age not reported; conference abstract)
Kim 2012 Wrong outcomes
Kim 2013 Intervention shorter than 12 weeks: 10‐week intervention period (2‐arm trial; n = 20; participants with MCI or dementia; mean age 69 years)
Kim 2013a Wrong outcomes
Kim 2015 Nature of intervention unclear
Kim 2015a Intervention shorter than 12 weeks: 8‐week intervention period (2‐arm trial; n = 28; cognitively healthy; mean age 72 years)
Kim 2015b Duplicate
Kivipelto 2014 Wrong intervention
Klusmann 2009 Duplicate
Klusmann 2010 Wrong patient population
Klusmann 2010a Duplicate
Klusmann 2011 Younger than 30 years of age
Kudelka 2014 Intervention shorter than 12 weeks: 8‐week intervention period (4‐arm trial; n = 96; cognitively healthy; mean age 65 years)
Kwak 2015 Nature of intervention unclear
Kwak 2017 Nature of intervention unclear
Kwok 2013 Intervention shorter than 12 weeks: 8‐week intervention period (2‐arm trial; n = 194; mean MMSE score 25.92; mean age 75 years)
Lampit 2013 Wrong study design
Lampit 2014 Wrong patient population
Lampit 2015 Wrong outcomes
Lavretsky 2016 Nature of intervention unclear
Law 2014 Intervention shorter than 12 weeks: 10‐week intervention period (2‐arm trial; n = 83; participants with MCI; mean age 74 years)
Law 2014a Duplicate
Lee 2013 Intervention shorter than 12 weeks: 6‐week intervention period (2‐arm trial; n = 30; mean MMSE‐K 26; mean age 72 years)
Lee 2013a Intervention shorter than 12 weeks: 8‐week intervention period (2‐arm trial; n = 31; cognitively healthy; mean age 65 years)
Lee 2013b Intervention shorter than 12 weeks: multiple reports for Lee 2013a
Lee 2014 Intervention shorter than 12 weeks: 8‐week intervention period (2 2‐arm pilots trials; n = 31 & n = 39; likely cognitively healthy; age not reported; conference abstract that is part of multiple reports for Lee 2015)
Lee 2015 Intervention shorter than 12 weeks: 8‐week intervention period (2‐arm trial; n = 39; cognitively healthy; mean age 65 years)
Legault 2011 Wrong patient population
Leon 2015 Wrong comparator
Leung 2015 Wrong patient population
Li 2010 Intervention shorter than 12 weeks: intervention period 5 weeks (2‐arm trial; n = 20; cognitively healthy; mean age 76 years)
Linde 2014 Nature of intervention unclear
Mace 2015 Intervention shorter than 12 weeks: 3‐week intervention period (2‐arm trial; n = 43; mild cognitive complaints; mean age 78 years)
Mahncke 2006 Intervention shorter than 12 weeks: 8 to 10 weeks (2‐arm trial; n = 182; cognitively healthy; mean age 71 years)
Man 2012 Wrong comparator
Mann 2012 Wrong study population
Margrett 2006 Wrong patient population
Mayas 2014 Intervention shorter than 12 weeks: 20 sessions provided in 10‐ to 12‐week intervention period (n = 27; 2‐arm trial; cognitively healthy; mean age 69)
McAvinue 2013 Intervention shorter than 12 weeks: 5‐week intervention period (n = 36; 2‐arm trial; likely cognitively healthy; mean age 70)
McDaniel 2014 Intervention shorter than 12 weeks: 8‐week intervention period (n = 96; 4‐arm trial, cognitively healthy, mean age 65 years)
McDougall 2012 Intervention shorter than 12 weeks: 6‐week intervention period (n = 41; 2‐arm trial; likely cognitively healthy; mean age 75)
Middleton 2012 Wrong intervention
Miller 2013 Intervention shorter than 12 weeks: 8‐week intervention period (n = 69; 2‐arm trial; cognitively healthy; mean age 81.8)
Mohs 1998 Wrong intervention
Mombelli 2012 No outcome given
Moon 2013 Intervention shorter than 12 weeks: 10‐week intervention period (n = 38; likely participants with MCI; age not reported; conference abstract only)
Mowszowski 2014 Intervention shorter than 12 weeks: 7‐week intervention period (n = 53; participants with memory complaints, MCI or late life depression; mean age 66)
Mowszowski 2014a Duplicate
Mozolic 2010 Intervention shorter than 12 weeks: 8‐week intervention period (n = 66; mean age 69; cognitively healthy participants)
Mozolic 2011 Intervention shorter than 12 weeks: multiple reports for Mozolic 2010
Muller 2011 Nature of intervention unclear
Na 2013 Duplicate
Na 2014 Nature of intervention unclear
Naismith 2014 Duplicate
Navarro 2006 Intervention shorter than 12 weeks: 14 sessions; intervention duration not reported, but maximal follow‐up duration was 84 days (2‐arm trial; n = 80; likely cognitively healthy; mean age 66 years)
NCT00544856 Nature of intervention unclear
NCT02417558 2015 Nature of intervention unclear
NCT02462135 2014 No outcome given
NCT02480738 2012 No outcome given
NCT02512627 2015 No outcome given
NCT02747784 2016 Wrong patient population
NCT02774083 2015 Wrong comparator
NCT02785315 2016 Wrong intervention
NCT02808676 2016 Wrong intervention
Neely 2013 Nature of intervention unclear
Ng 2015 Wrong intervention
Ngandu 2015 Wrong intervention
Ngandu 2015a Wrong intervention
Nishiguchi 2015 Wrong intervention
Nouchi 2012 Intervention shorter than 12 weeks: 4‐week intervention period (2‐arm trial; n = 32; cognitively healthy; mean age 69)
Nouchi 2013 Intervention shorter than 12 weeks
Nozawa 2015 Intervention shorter than 12 weeks: 8‐week intervention period (3‐arm trial; n = 37; cognitively healthy; mean age 68)
O'Caoimh 2015 Intervention shorter than 12 weeks
Oei 2013 Intervention shorter than 12 weeks: 4‐week intervention period (5‐arm trial; n = 75; cognitively healthy; mean age 21)
Oliveira 2013 Intervention shorter than 12 weeks: 10‐week intervention period. (2‐arm cohort study; n = 182; subjective memory complaints; mean age not reported, all over 50 years of age, conference abstract only)
Otsuka 2015 Wrong study design
Park 2009 Nature of intervention unclear
Park 2014 Intervention shorter than 12 weeks: 2‐week intervention period (2‐arm trial; n = 40; cognitively healthy; mean age 70)
Payne 2012 Wrong intervention
Payne 2017 Intervention shorter than 12 weeks
Peretz 2011 Wrong patient population
R000001637 Nature of intervention unclear
Rahe 2015 Intervention shorter than 12 weeks: 6.5‐week intervention period (2‐arm trial; n = 30; cognitively healthy; mean age 67 years)
Rahe 2015a Intervention shorter than 12 weeks: 7‐week intervention period (3‐arm trial; n = 81; cognitively healthy; mean age 68 years)
Rebok 2013 Intervention shorter than 12 weeks: multiple reports for excluded trial: Ball 2002 (trial ACTIVE)
Rebok 2014 Intervention shorter than 12 weeks: multiple reports for excluded trial: Ball 2002 (trial ACTIVE)
Redick 2013 Younger than 30 years of age
Requena 2016 Wrong intervention
Rizkalla 2015 Intervention shorter than 12 weeks: 4‐week intervention period (2‐arm trial; n = 56; cognitively healthy; mean age 73 years)
Rojas 2013 Wrong intervention
Rose 2015 Intervention shorter than 12 weeks: 1‐month intervention period (2‐arm trial; n = 59; cognitively healthy; mean age 67 years)
Rosen 2011 Intervention shorter than 12 weeks: 2‐month intervention period (2‐arm pilot trial; n = 12; participants with MCI; mean age 74)
Ryu 2013 Wrong study design
Sakka 2015 Wrong study design
Santos 2011 Wrong comparator
Schoene 2015 Duplicate
Schoene 2015a Duplicate
Schumacher 2013 Intervention shorter than 12 weeks: 10‐week intervention period (3‐arm trial; n = 63; cognitively healthy participants; mean age 72; conference abstract)
Shah 2012 Wrong patient population
Shatil 2013 Wrong patient population
Shatil 2014 Intervention shorter than 12 weeks: 8‐week intervention period (2‐arm trial; n = 140; cognitively healthy; mean age 68)
Shatil 2014a Duplicate citation
Sisco 2013 Intervention shorter than 12 weeks: multiple reports for excluded trial: Ball 2002 (trial ACTIVE)
Slegers 2009 Wrong intervention
Smith 2009 Intervention shorter than 12 weeks: 8‐week intervention period (2‐arm trial IMPACT; n = 487; cognitively healthy; mean age 75 years)
Smith‐Ray 2014 Intervention shorter than 12 weeks: 10‐week intervention period (2‐arm trial; n = 45; cognitively healthy; mean age 72)
Smith‐Ray 2015 Intervention shorter than 12 weeks: 10‐week intervention period (2‐arm trial; n = 51; cognitively healthy; mean age 82)
Smith‐Ray 2015a Duplicate
Solomon 2014 Wrong comparator
Song 2009 Wrong intervention
Stepankova 2014 Intervention shorter than 12 weeks: 5‐week intervention period (3‐arm trial; n = 68; cognitively healthy; mean age 68 years)
Stine‐Morrow 2014 Intervention shorter than 12 weeks: CCT intervention period 10 weeks (3‐arm trial; n = 461; cognitively healthy; mean age 73 years)
Strenziok 2013 Duplicate
Strenziok 2014 Intervention shorter than 12 weeks: 6‐week intervention period (3‐arm trial; n = 42; cognitively healthy; mean age 69 years)
Sturz 2011 Wrong patient population
Sturz 2011a Nature of intervention unclear
Sturz 2015 Duplicate
Styliadis 2015 Intervention shorter than 12 weeks: 8‐week intervention (5‐arm trial; n = 70; participants with MCI; mean age 71 years)
Styliadis 2015a Duplicate
Suo 2012 Wrong outcomes
Szelag 2012 Intervention shorter than 12 weeks: 8‐week intervention period (3‐arm trial; n = 30; cognitively healthy; mean age 69 years)
Talib 2008 Intervention shorter than 12 weeks: 4‐session intervention period (2‐arm trial; n = 23; cognitively healthy; mean age 68 years)
Tappen 2014 Wrong intervention
Tennstedt 2013 Study protocol: multiple reports for excluded trial: Ball 2002 (trial ACTIVE)
Tesky 2012 Wrong intervention
Tsai 2008 Wrong study design
Tsolaki 2013 Nature of intervention unclear
Tucker‐Drob 2009 Wrong study design
van den Berg 2016 Intervention shorter than 12 weeks: 2‐week intervention period (2‐arm trial; n = 58; rehabilitation inpatients with MMSE ≥ 21 (mean MMSE 26 with SD = 3 in experimental and 27 with SD = 3 in control); mean age 80 years)
van der Ploeg 2016 Wrong study design
Van het Reve 2014 Wrong patient population
Vance 2007 Intervention shorter than 12 weeks: 2 to 3 months (n = 159; cognitively healthy but with speed of processing impairment; mean age 75 years)
Vidovich 2009 Intervention shorter than 12 weeks: multiple reports for excluded trial: Vidovich 2015 (PACE trial)
Vidovich 2015 Intervention shorter than 12 weeks: 5‐week intervention period (2‐arm trial; n = 160; participants with MCI; mean age 75 years; PACE trial)
Vidovich 2015a Duplicate
von Bastian 2013 Intervention shorter than 12 weeks: 4‐week intervention period (2‐arm trial; n = 57 in the elderly subgroup; cognitively healthy; mean age 69 years in the elderly subgroup)
Wadley 2007 Wrong study design
Walton 2015 Intervention shorter than 12 weeks: 4‐week intervention period (2‐arm trial; n = 28; cognitively healthy; mean age 64 years)
Wang 2013 Wrong intervention
Weicker 2013 Intervention shorter than 12 weeks: 4‐week intervention period (2‐arm trial; n = not reported; cognitively healthy; age 60 to 75 years; conference abstract)
Wild‐Wall 2012 Wrong outcomes
Williams 2014 Intervention shorter than 12 weeks: 3‐week intervention period (3‐arm trial; n = 103; mild impairment in cognition, expressed concern about cognitive changes, or mild dementia ‐ mean MMSE = 25.3; mean age 86 years)
Willis 1986 Intervention shorter than 12 weeks: 2‐week intervention period (2‐arm trial; n = 229; cognitively stable and cognitively declined participant subgroups; mean age 73 years)
Willis 2006 Intervention shorter than 12 weeks: multiple reports for excluded trial: Ball 2002 (trial ACTIVE)
Willis 2006a Duplicate
Willis 2007 Duplicate
Willis 2013 Intervention shorter than 12 weeks: multiple reports for excluded trial: Ball 2002 (trial ACTIVE)
Wojtynska 2011 Intervention shorter than 12 weeks: 6‐week intervention period (2‐arm trial, stratified by 3 cognitive strata; n = 34 MCI, n = 29 AD, n = 12 cognitively healthy; participants with MCI and early dementia; mean age 69 years; conference abstract)
Wolinsky 2006 Intervention shorter than 12 weeks: multiple reports for excluded trial: Ball 2002 (trial ACTIVE)
Wolinsky 2006a Intervention shorter than 12 weeks: multiple reports for excluded trial: Ball 2002 (trial ACTIVE)
Wolinsky 2010 Intervention shorter than 12 weeks: multiple reports for excluded trial: Ball 2002 (trial ACTIVE)
Wolinsky 2010a Intervention shorter than 12 weeks: multiple reports for excluded trial: Ball 2002 (trial ACTIVE)
Wolinsky 2013 Intervention shorter than 12 weeks: multiple reports for excluded trial: Wolinsky 2015 (IHAMS study)
Wolinsky 2015 Intervention shorter than 12 weeks: 5‐ to 6‐week intervention period with booster at 11 months (4‐arm trial; n = 681; cognitively healthy; 50 to 64 years, n = 455; and 65 years and above, n = 226; Iowa Healthy and Active Minds Study (IHAMS study)
Yam 2014 Wrong intervention
Yassuda 2015 Intervention shorter than 12 weeks: 8‐session intervention period (2‐arm trial; n = 60; participants without depression/dementia; mean age not reported; conference abstract)
Yip 2012 Intervention shorter than 12 weeks: 5‐week intervention period (3‐arm trial; n = 56; participants with acquired brain injury and subjective memory complaints; mean age 52 years)
Yoonmi 2012 Intervention shorter than 12 weeks: 6‐week intervention period (2‐arm trial; n = 30; cognitively healthy; aged 65 to 80 years)
Youn 2011 Intervention shorter than 12 weeks: 5‐week intervention period (2‐arm trial; n = 40; participants with subjective memory complaints; mean age 69 years)
Zelinski 2011 Wrong study design
Zelinski 2011a Intervention shorter than 12 weeks: multiple reports for excluded trial: Smith 2009 (IMPACT)
Zhuang 2013 Wrong patient population
Zimmermann 2014 Intervention shorter than 12 weeks: 6‐week intervention period (2‐arm trial; n = 20; cognitively healthy; mean age 68 years)

MMSE: Mini Mental State Examination.