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(A) UV/VIS spectrum of hypoxia-responsive mesoporous silica nanoparticles (HR-MSN) incubated under normoxic and hypoxic conditions for 3 h. Measurements were performed in PBS buffer containing 100 μM NADPH as an electron donor. The illustration shows the reduction of nitro to amine under hypoxic conditions; (B) Time-dependent change in surface charge potentials of HR-MSN incubated under normoxic and hypoxic conditions; and, (C) In vitro DOX release profiles from DOX-CD-HR-MSN.
