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Macroscopic evaluation of acute ocular tolerance of rabbits to instilled FLFs.
| Sign/Symptoms | Grade * | Observation |
|---|---|---|
| Discomfort | 0 | No reaction |
| Corneal alterations | 0 | No alteration |
| Conjunctival alterations | 0 | No alteration |
| Discharge | 0 | No discharge |
| Lid alterations | 0 | No swelling |
Drops (30 μL) were instilled every 30 min for 6 h. Observations were made prior to the first instillation and at 3, 6, and 24 h afterwards; * highest score recorded for the three evaluation periods.
