Table 2.

Representative in vitro studies evaluating the impact of statins on periodontal pathogens.

Local drug delivery
Reference	Experimental design	Type of statin dose	Results	Periodontal consideration
[82]	MIC was determined against P.g (ATCC 33277) and A.a (ATCC 25586) using serial dilution method	Simvastatin, 1 μg/mL to 500 μg/mL	↘ P.g ↘ A.a	Simvastatin had an antibacterial effect against the keystone pathogens involved in periodontal disease
[138]	A.a (ATCC 43719), P. nigrescens (ATCC 33563), or P.g (ATCC 33277) were cultured on a trilayer functional CS membrane with EGCG and lovastatin	Lovastatin 0.1, 0.5, 1, and 2 mg	↘ P.g ↘ A.a	Lovastatin had an antibacterial effect against periodontopathogenic bacteria