Table 1.
Biochemical parameters in patients with subacute thyroiditis (SAT) at baseline (T0) compared to healthy control subjects (CS).
| Parameter | Reference range | SAT (T0) | CS | p value |
|---|---|---|---|---|
| HepcidinEL (ng/mL) | 0.2-47.7 | 48.8 (15.9-74.5) | 18.2 (10.2-23.3) | 0.009 1 |
| WBC (×103/μL) | 3.9-11.0 | 8.2 (7.1-9.1) | 6.7 (5.2-8.7) | NS1 |
| ∗RBC (×106/μL) | 3.5-5.2 | 4.3 ± 0.4 | 4.5 ± 0.3 | 0.032 2 |
| ∗HGB (g/dL) | 12.0-15.6 | 12.3 ± 1.3 | 14.0 ± 1.0 | <0.001 2 |
| ∗HCT (%) | 33.0-46.0 | 37.1 ± 3.6 | 41.4 ± 2.7 | <0.001 2 |
| MCV (fL) | 80.0-99.0 | 86.8 ± 4.2 | 91.1 ± 2.7 | <0.001 2 |
| MCH (pg) | 27.0-33.5 | 29.4 (28.2-29.7) | 30.8 (30.0-31.8) | <0.001 1 |
| MCHC (g/dL) | 31.0-38.0 | 33.0 (32.6-33.6) | 33.9 (33.3-34.3) | 0.002 1 |
| RDW-CV (%) | 11.0-16.0 | 12.1 (11.7-12.4) | 12.9 (12.8-13.4) | <0.001 1 |
| PLT (×103/μL) | 130.0-400.0 | 371.4 ± 100.4 | 251.7 ± 53.6 | <0.001 2 |
| PDW (fL) | 9.0-17.0 | 11.5 ± 1.9 | 13.1 ± 2.1 | 0.013 2 |
| MPV (fL) | 9.0-13.0 | 10.0 ± 0.9 | 10.8 ± 1.0 | 0.009 2 |
| P-LCR (%) | 13.0-43.0 | 25.5 ± 7.5 | 31.8 ± 8.2 | 0.013 2 |
| CRP (mg/L) | <5.0 | 38.5 (12.2-50.9) | 1.6 (0.6-3.6) | <0.001 1 |
| ALT (U/L) | 10.0-41.0 | 18.0 (11.0-24.0) | 21.0 (14.0-24.0) | NS1 |
| AST (U/L) | 10.0-37.0 | 17.0 (13.0-20.0) | 19.0 (26.0-23.0) | NS1 |
| TSH (μIU/mL) | 0.2-4.2 | 0.02 (0.01-0.08) | 1.2 (1.0-1.6) | <0.001 1 |
| fT3 (pmol/L) | 3.9-6.7 | 9.8 ± 4.5 | 4.9 ± 0.6 | <0.001 2 |
| fT4 (pmol/L) | 11.5-21.0 | 28.4 (23.0-39.4) | 16.1 (14.8-18.0) | <0.001 1 |
| aTPO (IU/mL) | <34.0 | 14.0 (9.0-20.0) | 13.0 (10.0-16.0) | NS1 |
| aTG (IU/mL) | 10.0-115.0 | 33.0 (19.0-84.0) | 13.5 (10.0-24.0) | 0.012 1 |
| TRAb (IU/L) | <2.0 | 0.3 (0.2-0.5) | 0.3 (0.2-0.4) | NS1 |
| ∗Ferritin (ng/mL) | 13.0-150.0 | 115 (48.0-197.0) | 88.0 (44.0-125.0) | NS1 |
| ∗Fe (μg/dL) | 37.0-145.0 | 37.0 (29.0-70.0) | 98.0 (70.0-139.0) | <0.001 1 |
| Creatinine (mg/dL) | 0.5-1.2 | 0.6 (0.5-0.7) | 0.7 (0.70.8) | NS1 |
Values are expressed as median (IQR) for nonparametric tests and mean ± SD for parametric tests. 1Mann–Whitney U test; 2independent T-test. ∗Parameters with different reference ranges in men and women, test performed only in the female subgroup. NS: nonsignificant; WBC: white blood cells; RBC: red blood cells; HGB: haemoglobin; HCT: haematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular haemoglobin; MCHC: mean corpuscular haemoglobin concentration; RDW-CV: red blood cell distribution width-coefficient of variation; PLT: platelets; PDW: platelet distribution width; MPV: mean platelet volume; P-LCR: platelet larger cell ratio; CRP: C-reactive protein; ALT: alanine aminotransferase; AST: aspartate aminotransferase; TSH: thyroid-stimulating hormone; fT3: free triiodothyronine; fT4: free thyroxine; aTPO: anti-thyroid peroxidase antibody; aTG: anti-thyroglobulin antibody; TRAb: thyrotropin receptor antibody; Fe: iron.