Fig. 8.

Schematic representation of the mechanisms underlying apoptosis induced by WP1130 targeting USP24 in T-ALL. USP24 play an important role in the survival of T-ALL by deubiquitinating of its substrate Mcl-1 which helps to maintain mitochondrial integrity. WP1130 directly interacts and inhibits the deubiquitination activity of USP24, which in turn increasing the degradation of the it’s substrate Mcl-1, and ultimately accelerating the collapse of mitochondrial transmembrane potential that induce apoptosis of T-ALL cells both in vivo and in vitro