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. 2018 Apr 27;10(5):478. doi: 10.3390/polym10050478

Table 4.

Apparent permeability coefficient (Papp) of unmodified and thiolated nanoparticles before and after crosslinking in Caco-2 and co-culture models.

Sample Crosslinking Concentration (% w/v) Papp ± S.D. (10−6 cm/s)
Caco-2 monolayer
Unmodified CS-g-PMMA Yes 0.01 2.997 ± 0.455
No 0.05 2.087 ± 0.226
Yes 0.05 1.215 ± 0.245
Thiolated CS-g-PMMA Yes 0.01 3.498 ± 0.682
No 0.05 2.591 ± 0.160
Yes 0.05 0.921 ± 0.399
Co-Culture monolayer
Unmodified CS-g-PMMA Yes 0.01 3.660 ± 0.915
No 0.05 2.060 ± 0.147
Yes 0.05 1.462 ± 0.243
Thiolated CS-g-PMMA Yes 0.01 2.125 ± 0.460
No 0.05 0.713 ± 0.251
Yes 0.05 0.912 ± 0.150