Table 4.

Apparent permeability coefficient (P_app) of unmodified and thiolated nanoparticles before and after crosslinking in Caco-2 and co-culture models.

Sample	Crosslinking	Concentration (% w/v)	Papp ± S.D. (10−6 cm/s)
		Caco-2 monolayer
Unmodified CS-g-PMMA	Yes	0.01	2.997 ± 0.455
	No	0.05	2.087 ± 0.226
	Yes	0.05	1.215 ± 0.245
Thiolated CS-g-PMMA	Yes	0.01	3.498 ± 0.682
	No	0.05	2.591 ± 0.160
	Yes	0.05	0.921 ± 0.399
		Co-Culture monolayer
Unmodified CS-g-PMMA	Yes	0.01	3.660 ± 0.915
	No	0.05	2.060 ± 0.147
	Yes	0.05	1.462 ± 0.243
Thiolated CS-g-PMMA	Yes	0.01	2.125 ± 0.460
	No	0.05	0.713 ± 0.251
	Yes	0.05	0.912 ± 0.150