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(a) Synthetic procedures of the biotin-containing hydrogel for label-free sensor array; (b,c) Chemical structures of (b) the biocompatible monomer containing a monosaccharide and (c) the multi-functional monomer containing a chromophore and anchoring group; (d) RAFT polymerization of N-isopropylacrylamide (NIPAM) and the fluorescent monomer. The resulting polymer shows fluorescence in response to temperature change.
