Table 3.
Comparative urine FA concentrations detected by using FA probe and Fluo-HPLC methods in patients with Alzheimer’s disease and age-matched controls, respectively.
| Test items/groups | Controls (n = 52) | AD (n = 30) | P |
|---|---|---|---|
| Age (years old) | 77.01 ± 3.45 | 80.02 ± 2.36 | >0.05 |
| Sex (male/female) | 21/31 | 12/18 | >0.05 |
| Education (years) | 8.65 ± 2.76 | 8.38 ± 2.82 | >0.05 |
| MMSE scores | 29.19 ± 2.15 | 6.16 ± 1.37 | <0.01 |
| CDR scores | 0.08 ± 0.03 | 2.50 ± 0.14 | <0.01 |
| ADL scores | 94.84 ± 2.37 | 63.63 ± 3.13 | <0.01 |
| FA probe-urine FA (μM) | 29.52 ± 6.62 | 96.91 ± 12.61 | <0.01 |
| HPLC-urine FA (μM) | 24.43 ± 2.47 | 56.67 ± 10.27 | <0.01 |
FA: formaldehyde; AD: Alzheimer’s disease; MMSE: Mini-Mental State Examination; CDR: Clinical Dementia Rating; ADL: Activities of Daily Living.