Skip to main content
. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: J Pediatr. 2018 Dec 5;206:156–163.e3. doi: 10.1016/j.jpeds.2018.10.045

Table 5.

Interaction between alpha- and gamma-tocopherol on 2-year wheezing

Univariate analysis: Distribution of alpha-tocopherol concentrations by 2-year wheezing status in subjects with low, medium, and high gamma-tocopherol
concentrations (tertiles)

Gamma-tocopherol concentration
(tertiles, ng/mg creatinine)
Low Medium High

Alpha-tocopherol concentration (ng/mg creatinine) [IQR] No wheezing 49 [36,74] 73 [55,98] 106 [83,123]
Alpha-tocopherol concentration (ng/mg creatinine) [IQR] Wheezing 42 [26,53] 67 [45,82] 107 [87,121]
P value 0.004 0.059 0.42

Multivariable regression analysis: The protective association of alpha-tocopherol with 2-year wheezing outcome differs by gamma-tocopherol level

Gamma-tocopherol concentration
(tertiles, ng/mg creatinine)
Low Medium High

Unadjusted ORs* 0.51 (0.32,0.80) 0.54 (0.28,1.05) 1.64 (0.71,3.81)
Alpha-tocopherol concentration (ng/mg creatinine) IQR difference aORs* 0.49 (0.30,0.80) 0.59 (0.29,1.18) 1.65 (0.67,4.01)
*

ORs were estimated for the association of alpha tocopherol with 2-year wheezing in low, medium, and high tertiles of gamma-tocopherol. Multivariable logistic regression was used for the adjusted association including infant sex, race, birth weight, breastfeeding status, maternal smoking during pregnancy, maternal asthma, and insurance status. P interaction (likelihood ratio test) cross-product alpha (continuous)—and gamma-tocopherol tertiles = 0.05. Alpha-tocopherol was natural log transformed.