Table 2. Logistic Regression * model for CAD in subgroups of Framingham 10-year risk (< 10; 10-20%;>20%) and in total population.
| Variables | FRS<10% | FRS 10%-20% | FRS>20% | Total | ||||
|---|---|---|---|---|---|---|---|---|
| OR | p-value | OR | p-value | OR | p-value | OR | p-value | |
| (95% CI) | (95% CI) | (95% CI) | (95% CI) | |||||
| Hypertension | 3.25 (2.52 - 4.18) | <0.0001 | 1.88 (1.39 - 2.56) | <0.0001 | --- | --- | 2.10 (1.77 - 2.48) | <0.0001 |
| Diabetes | 2.93 (1.90 - 4.52) | <0.0001 | 4.34 (3.14 - 6) | <0.0001 | 3.56 (2.34 - 5.4) | <0.0001 | 3.19 (2.61 - 3.91) | <0.0001 |
| Dyslipidemia | 1.71 (1.28 - 2.29) | <0.0001 | --- | --- | --- | --- | 1.30 (1.03 - 1.65) | 0.030 |
| Smoking status | 4.92 (3.66 - 6.62) | <0.0001 | 3.57 (2.65 - 4.8) | <0.0001 | 3.11 (2.04 - 4.73) | <0.0001 | 3.44 (2.89 - 4.1) | <0.0001 |
| GRS | 1.76 (1.41 - 2.2) | <0.0001 | 1.86 (1.39 - 2.49) | <0.0001 | 2.49 (1.54 - 4.05) | <0.0001 | 1.87 (1.58 - 2.21) | <0.0001 |
| Constant | 0.16 | <0.0001 | 0.24 | <0.0001 | 0.342 | <0.0001 | 0.21 | <0.0001 |
*
Using Forward Wald Conditional Regression method (SPSS v. 19.0). FRS, Framingham risk score; OR, Odds ratio; CI, Confidence interval; GRS, Genetic risk score; Dashed points represent co-variables not significant after adjusted multivariate analysis; Statistically significant for p<0.05.